All-Time Record: 49ers lead series 21-6 (.222)
2024 Record: 6-11-0
Division Finish: 4th/NFC West
Playoffs: None
Head Coach: Kyle Shanahan
Key Additions: DE Bryce Huff, DE Mykel Williams, DT Alfred Jenkins, LB Nick Martin, CB Tre Brown, WR DeMarcus Robinson, WR Jordan Watkins, T Andre Dillard, TE Luke Farrell, P Thomas Morstead
Notable Players: QB Brock Purdy, RB Christian McCaffrey, TE George Kittle, T Trent Williams, DE Nick Bosa, LB Fred Warner
Key Departures: WR Deebo Samuel, G Aaron Banks, CB Charvarius Ward, DT Javon Hargrave, LB Dre Greenlaw, S Talanoa Hufanga, T Jaylon Moore, OLB Leonard Floyd, CB Isaac Yiadom, RB Elijah Mitchell, RB Jordan Mason
Buccaneers and 49er first matchup came in 1977