Selected in the sixth round (196th overall) of the 2017 NFL Draft by the New Orleans Saints.
Waived by the Saints on Sept. 1, 2018.
Claimed off waivers by the Indianapolis Colts on Sept. 2, 2018.
Signed as an unrestricted free agent by the Chicago Bears on March 18, 2022.
Waived by the Bears on Feb. 21, 2023.
Signed by the Colts on July 25, 2023.
Waived by the Colts on Aug. 29, 2023 and re-signed to the team's practice squad the next day.
Signed by the Dallas Cowboys on Aug. 2, 2024. Waived by the Cowboys on Aug. 28, 2024.
Signed to the Detroit Lions' practice squad on Oct. 7, 2024. Re-signed with the Lions on March 12, 2025.
Signed as an unrestricted free agent by the Tampa Bay Buccaneers on March 12, 2026.
1x NFC Defensive Player of the Week (Week 14, 2025).
Has played in 110 career regular season games between the New Orleans Saints, Indianapolis Colts, Chicago Bears and Detroit Lions, combining to start in 35 games and record 190 tackles (36 for loss), 58 quarterback hits, 26.0 sacks, four forced fumbles, two passes defensed and one fumble recovery.
Has appeared in four career postseason contests, with two starts, logging seven tackles (three for loss), two quarterback hits and 1.0 sack.
Recorded his first career sack in Week 1 of the 2019 season at the Los Angeles Chargers (9/8/19).
Made his first career start in Week 2 of the 2018 season at Washington (9/16/18).
Made his NFL debut in Week 1 of the 2017 season at Minnesota (9/11/17).
Played in all 17 games for the Lions in 2025, posting 23 tackles and producing career highs with 11.0 sacks, 20 quarterback hits and nine tackles for loss.
Among defenders with at least 250 pass rush snaps, Muhammad's 18.1% quarterback pressure rate in 2025 was the fifth-highest mark in the NFL. His 3.4% sack rate ranked seventh. His 11.0 sacks in 2025 were tied for the 11th-highest mark in the NFL.
Became just the eighth player since sacks became an official NFL statistic in 1982 to record 11.0-or-more sacks during a season in which he did not start a single game.
Played in 25 career games across two seasons for the University of Miami (2013, 2015), totaling 62 tackles, 7.0 sacks, one pass defensed and one forced fumble.
Appeared in 13 games for the Hurricanes in 2015, recording 54 tackles (8.5 for loss), 5.0 sacks, one pass defensed and one forced fumble.
Saw action in a limited capacity in 2013, appearing in 13 games and logging eight tackles to go with 2.0 sacks.
Attended Don Bosco Prep (Ramsey, N.J.)
As a senior in high school, led his team to the state semifinals and recorded 10.0 sacks.
A four-star recruit, was the third-ranked defensive end in the country per Rivals.com in 2013. Was the highest-rated prospect in the state of New Jersey.
Played in the U.S. Army All-American game in 2013.
