Get all the in-game updates, highlights, stats and analysis for the Tampa Bay Buccaneers' Week 6 game vs. the San Francisco 49ers

WR Kameron Johnson catches a 34-yard touchdown pass from QB Baker Mayfield against the San Francisco 49ers in Week 6 of the 2025 NFL season.

RB Sean Tucker scores a rushing touchdown against the San Francisco 49ers in Week 6 of the 2025 NFL season.

RB Rachaad White rushes for a touchdown against the San Francisco 49ers in Week 6 of the 2025 NFL season.

CB Kindle Vildor grabs an INT against the San Francisco 49ers in Week 6 of the 2025 NFL season.

Find out how to watch, stream, or listen to the San Francisco 49ers at Tampa Bay Buccaneers Week 6 NFL game on Oct. 12, 2025. Get kickoff time, TV channel, and live audio details. 

The Bucs will play their first game of the 2025 without both Mike Evans and Chris Godwin when they face the 49ers on Sunday, and their offense will also be missing lead back Bucky Irving

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View the best photos of the Tampa Bay Buccaneers' 2025 Week 6 matchup vs. San Francisco 49ers

View pregame pictures from the San Francisco 49ers vs. Tampa Bay Buccaneers Week 6 matchup.

Two of the NFC's best collide. Only one will come out on top. The Krewe is ready for battle against the San Francisco 49ers.

View photos of the Buccaneers arriving for their 2025 Week 6 Game against the San Francisco 49ers

Simeon Rice was the NFL's most dominant pass rusher for nearly a decade, and his career accomplishments match his contemporaries who have been enshrined in the Pro Football Hall of Fame

With Bucky Irving and Josh Williams ruled out for Sunday's game due to injuries, first-year back Owen Wright was elevated from the practice squad to boost the team's backfield depth on Sunday against the 49ers

A look at Friday's injury report ahead of the Week Six matchup

A film review of a few of Baker Mayfield's sensational throws in Week Five against the Seattle Seahawks at Lumen Field

Tampa Bay Buccaneers Head Coach Todd Bowles spoke to the media after Friday's Week 6 practice. HC Bowles discussed who is unavailable for Sunday's game vs. San Francisco and players rising to the occasion.

Keep informed with our daily updates: News, notes and more throughout the month of October

The Buccaneers and 49ers will engage in a battle of first-place teams on Sunday afternoon, and the experts are split on which of these top NFC contenders will come out on top

Brianna Dix and Scott Smith continue their season-long competition – currently being controlled by Briana – of predicting which players will have star turns in the Bucs' next outings